Petasites hybridus (butterbur) is a perennial shrub found throughout Europe aswell as in parts of Asia and North America. It was used during the Middle Ages to treat the dreaded plague and fever, and in the 17th century its use was noted in treating cough, asthma, and skin wounds. The plant can grow to a height of three feet and is usually found in marshes, damp forests, and adjacent to riverbeds or streams. Its leaves can attain a diameter of three feet, making it the largest of all indigenous floras.
What does Petadolex do?
Mechanism of Action Butterbur extracts are primarily known for the treatment of three clusters of conditions: migraines; allergy/asthma/bronchitis; and gastro-intestinal disorders. All three are dependent on the anti-inflammatory and anti-spasmodic effects of butterbur. The former is arguably paramount, and what makes butterbur sounique is that it seems to suppress leukotriene production without impeding the biosynthesis of the more ‘constructive' eicosanoids, especially prostaglandins.
Who should use Petadolex?
Petadolex is recommended to people presenting symptoms of one of the three conditions above.
Safety Reports of side effects from petasites extracts have been extremely sporadic.
The butterbur plant's pyrrolizidine alkaloids are thought to potentially cause hepatic damage and be carcinogenic in animals; however, extracts are commercially available in which the pyrrolizidine alkaloids have been removed. In fact, the German pharmaceutical giant Weber & Weber® have a patented procedure to remove these alkaloids in their own finished butterbur extract known as Petadolex.TM There are no known interactions with either pharmaceutical or over-the-counter anti-inflammatory agents; however, the use of petasites extracts during pregnancy and lactation is discouraged for lack of study.
Petasites extracts are standardized to contain a minimum of 7.5 mg of petasin and isopetasin. The adult dosage ranges from 50-100 mg twice daily with meals. When used to treat migraines, four to six months of supplementation along a tapering pattern is recommended. Dosage regimens for asthma and gastrointestinal disorders are as yet undefined, dictating the need for further research.
50 mgButterbur root extract (Petasites hybridus 28:1)
Standardized for at least 7.5 mg of Petasin and Isopetasin, PA-free
Non-medicinal ingredients: riboflavin (colouring), glycerol, sorbitol, titanium dioxide. Softgel: gelatin.
Manufactured by: Weber & Weber Int. GmbH & CO.KG, Germany.