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Estrogens are very important hormones. Although they are present in both men and women, their best known role is as the primary female sex hormones, and they are thus involved in the development of female characteristics and in the regulation of the menstrual cycle. Estrogens have over 400 different functions in the body, some of which include the maintenance of tissue strength, cardiovascular health, mood, bone health and vision.

However, there are many different kinds of estrogens, which can be confusing. The general term “estrogen” tends to be used to describe all types of estrogens, including naturally occurring estrogen produced in the body, estrogens produced by plants (phytoestrogens) and environmental estrogens (xenoestrogens). What is important to note is that while some estrogens are healthy and beneficial, other types can have negative effects.

For example, xenoestrogens, which are synthetic estrogens encountered in the environment, are particularly dangerous. These compounds can be present in synthetic hormones, pesticides and plastics. They do not react in our body the same way as natural estrogens, and can be difficult to eliminate from the body. Xenoestrogens have been associated with disrupted reproductive processes and an increased risk of cancer.

But it is not just xenoestrogens that can cause problems. Estrogen has long been considered a risk factor for a variety of women’s cancers, especially breast cancer. In fact, the risk of breast cancer has been shown to increase with the number of premenopausal years, when estrogen levels are highest. Research has shown that natural estrogens can also be classified as “good” or “bad”. For example, experimental and clinical evidence has shown that 16α-hydroxylated estrogen metabolites have stronger estrogen activity and are associated with an increased risk of breast cancer, while 2-hydroxylated estrogen metabolites are weaker and are not associated with increased risk of estrogen positive cancers..

Fortunately, there are natural solutions available that can help tip the balance towards the “good” estrogens, and to help detoxify and eliminate “bad” estrogens and xenoestrogens. The ingredients in Estro Detox work together to promote a healthy estrogen balance and to promote the detoxification of harmful substances, thereby helping to reduce the risk of women’s cancers.

D-Glucarate

D-glucarate is a naturally occurring compound that is produced by the body in small amounts and is also found in many fruits and vegetables. D-glucarate plays a very important role in the detoxification of toxins and carcinogens. One very important detoxification pathway in the body is the glucuronidation pathway. Through glucuronidation toxic substances, environmental carcinogens and even excess levels of estrogen are neutralized, and then eliminated from the body.

Unfortunately, this important detoxification process can be disrupted by the enzyme beta-glucuronidase, which acts to reactivate the neutralized toxins. Elevated levels of this enzyme have been associated with an increased incidence of breast, prostate and colon cancers. This is where D-glucarate comes in. The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification.

Research has shown that D-glucarate can inhibit breast cancer development in mice by as much as 70%. Calcium-D-glucarate’s inhibition of beta-glucuronidase also allows the body to excrete estrogen before it is reabsorbed by the body. In this way D-glucarate can help to encourage healthy estrogen metabolism, and prevent elevated estrogen levels. D-glucarate has been shown to lower serum estrogen levels in rats by 23%. Preliminary studies in humans show that D-Glucarate supplements are safe, and have the same effects on beta-glucuronidase in people that they do in animals. Studies on D-glucarate supplements in women at risk for breast cancer are underway, and it has been suggested that D-glucarate may provide a safe, effective and side-effect free alternative to the drug tamoxifen.

3,3’-Diindolymethane (DIM)

DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM has been shown to promote the formation of 2-hydroxylated estrogen metabolites instead of 16α-hydroxylated estrogen metabolites. This means that DIM helps to push the balance of estrogen in the body towards the production of “good” estrogens and reduces the production of “bad” estrogens. In cell culture studies DIM has powerful anti-cancer effects, and has been shown to stop breast and cervical cancer cell growth in vitro. It has also been shown to block the activation of genes that promote cancer cell growth while activating genes that help prevent cancer.

Human studies also show promising results. DIM is currently used to treat Recurring Respiratory Papillomatosis caused by the Human Papilloma Virus and is in Phase III clinical trials for Cervical Dysplasia. Cervical Dysplasia is a precancerous condition also caused by the Human Papilloma Virus, and is highly correlated to the development of cervical cancer. Preliminary open-label testing has shown that treatment with DIM successfully resolved moderate to severe cervical dysplasia.

Sulforaphane

Sulforaphane is another naturally occurring substance found in the brassica family of vegetables, such as broccoli. Sulforaphane has been shown to stimulate the natural defenses of the body to prevent or improve chronic disease. It is a natural anti-oxidant and a potent inducer of phase II liver detoxification enzymes. The phase II detoxification enzymes are responsible for eliminating harmful toxins and carcinogens from the body. Additionally, research has shown that sulforaphane acts directly to inhibit cancer cell growth and to initiate apoptosis, or death, of cancer cells through a variety of mechanisms.

In regards to women’s health, sulforaphane has been shown to inhibit the proliferation of breast cancer cells, and to reduce their expression of the estrogen receptor, thereby interfering with the ability of estrogen to bind the receptor and initiate cellular proliferation and growth.

Hops Extract – 8-prenylnarigenin

8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen, or plant estrogen. It has been shown to be of equal or greater potency as soy-derived phytoestrogens like genistein. In vitro 8PN has been shown to inhibit breast cancer cell proliferation by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogensis (the formation of new blood vessels to feed tumors) both in test tube and animal studies.

Furthermore, 8PN has benefits for women with menopause. One double blind randomized cross over study (specifically designed to take into account the high degree of "placebo" effect common with menopausal studies) showed that 8PN reduced hot flashes, night sweats and other menopausal symptoms significantly. In animal studies, it has also been shown to help reduce atherosclerosis and reduce cholesterol levels. It has been proposed that 8PN may help to prevent the incidence of cardiovascular disease associated with low estrogen levels. Lifenol®’s hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.

 

Amount: 
120 mgLIFENOL®† Hops extract (15-25:1)
150 mgCalcium D-Glucarate
108 mgDIM (3,3’-Diindolylmethane)
27.6 mgCholine (bitartrate)
Non-medicinal ingredients: broccoli extract* (300 mg), microcrystalline cellulose, maltodextrin, silica. Capsule: hypromellose.
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