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Resveratrol is a polyphenol found in various berries and herbs that has a number of benefits in heart health, immunity and inflammation. Resveratrol is the active ingredient in wine that has led to its reputation for promoting longer life.
Primary Uses: The most exciting benefit of resveratrol is its ability to mimic the longevity effects of a calorie restricted diet, and to increase lifespan in a number of species. Resveratrol is a powerful anti-aging antioxidant.
Secondary Uses: Its role in cardiovascular health involves reducing cholesterol, triglycerides, LDL oxidation, and promoting healthy blood vessel function and blood pressure. Resveratrol can also decrease the production of inflammatory signals. It also blocks enzymes that promote the carcinogenic activity of certain compounds, while increasing the activity of enzymes that help to remove toxins and carcinogens from the body
Those in search of anti-aging nutrients, practicing life extension, those desiring the heart health benefits of wine without the negative effects of sugar and alcohol, could benefit from Acta-ResveratrolTM.
Resveratrol has been shown to down-regulate the production of chemicals (cytokines) involved in the cause, signaling and amplification of inflammation. Resveratrol's anti-cancer effects have been shown to occur at all three stages of cancer - initiation, promotion and progression. Prevention of blood flow to the tumour (angiogenesis) restricting the growth and spread of the cancer cells and inhibition of various enzymes involved (e.g. cyclooxygenses or ornithine decarboxylase) have been attributed to resveratrol. Finally, the modulation of the activity of the two groups of enzymes - Phase 1 and Phase 2 - also plays an important role in the detoxification and anti-cancer effects of resveratrol. The Phase 1 family of enzymes normally makes compounds more carcinogenic or toxic and resveratrol has an inhibiting effect on them, thereby preventing carcinogen formation. Alternatively, stimulation of the Phase 2 class of enzymes help facilitate the removal of toxins and carcinogens from the body by making these compounds even more soluble and easier for excretion.
The plants that produce resveratrol do so as a response to stressors such as fungal infection or ultra violet exposure. Resveratrol has been shown to enhance life extension much like caloric restriction in yeast (70%), worms (18%), fruit flies (30%), and fish (60%). The mechanism may be similar to sirtuin activation. There is considerable excitement regarding the use of resveratrol as a CR Mimetic. A recent study published in the prestigious journal Nature jointly by Harvard University and the National Institute of Aging demonstrated that resveratrol in high doses offset the effects of an unhealthy high-calorie diet in mice. Resveratrol is a molecule that occurs in nature in two forms or as mirror-images, namely the trans and cis forms. It is the trans version of the resveratrol that is the active form that has been used in all the investigations. The cis form may be at best inactive or at worst inhibit the activity of its mirror image - the trans form. There are high quality, naturally extracted sources that yield 98% plus trans activity.
As we conclude, we are reminded of the ‘one glass of wine a day for longer life' anecdote. In order to obtain the substance identified as responsible for this effect in amounts that are commensurate with even the most conservative trials, one needs to consume approximately 1,000 glasses of red wine each day! A noble goal for some, but perhaps one capsule containing enough resveratrol to equal that found in approximately 450 glasses of red wine might be a more practical start.
1 Vegi-Cap
40 mgtrans-Resveratrol
40 mgVitamin C (ascorbic acid)
Non-Medicinal Ingredients
53 mgQuercetin
10 mgRosemary Extract
oleoresin black pepper, calcium disodium EDTA dehydrate, gum Arabic, microcrystalline cellulose, maltodextrin, silica. Capsule: hypromellose, titanium dioxide.
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